Make the sauce: In a small bowl, whisk Greek yogurt, mayo, ketchup, mustard, pickle juice, honey, garlic powder, onion powder, salt, and pepper. Adjust to taste.
Chill while you prep everything else.
Season the beef: In a mixing bowl, combine ground beef with salt, pepper, onion powder, garlic powder, smoked paprika, ketchup, mustard, and Worcestershire. Mix gently until just combined.
Cook the beef: Heat a large skillet over medium-high. Add the beef and break it into small crumbles.
Cook 6–8 minutes until browned and cooked through. If needed, drain excess fat.
Optional melt: Sprinkle shredded cheddar over the hot beef, cover the pan for 1 minute to soften the cheese. Or keep cheese separate for topping.
Prep the veg: Chop lettuce, halve tomatoes, slice red onion, and dice pickles and avocado if using.
Assemble bowls: Divide lettuce among 4 bowls.
Top with beef, tomatoes, onion, pickles, cheese, and avocado.
Dress and finish: Drizzle the sauce over each bowl. Add sesame seeds or bacon if you like. Taste and add a pinch of salt, extra pickle juice, or hot sauce to finish.